High-Protein Pizza Pasta Bake

Featured in: Simple Comfort Plates

This comforting bake brings together the best of pizza and pasta in one satisfying dish. Lean ground beef and sliced pepperoni create savory layers, while a creamy Greek yogurt and mozzarella sauce adds richness without the heaviness of traditional cheese sauces. The pasta absorbs all those classic pizza flavors—oregano, basil, garlic, and tomatoes—as it bakes to golden perfection.

What makes this special is the clever use of Greek yogurt in the sauce, keeping things light while packing in 37 grams of protein per serving. It's an easy weeknight dinner that feels indulgent but fits a high-protein lifestyle.

Updated on Sun, 08 Feb 2026 12:32:00 GMT
Golden, bubbly High-Protein Pizza Pasta Bake fresh from the oven, topped with crispy pepperoni and melted mozzarella. Pin it
Golden, bubbly High-Protein Pizza Pasta Bake fresh from the oven, topped with crispy pepperoni and melted mozzarella. | freshymeals.com

There's something about the smell of ground beef hitting a hot skillet that makes you feel like you're actually feeding people, not just cooking dinner. I stumbled onto this pizza pasta bake on a Tuesday when I had Greek yogurt that needed using and a craving for something that tasted indulgent but wouldn't leave me feeling heavy. The magic happens when that creamy, tangy sauce meets the pasta and beef—it's comfort food that doesn't apologize for being good for you.

I made this for my neighbor who had just gotten back from the gym and was tired of chicken breast and broccoli. She took one bite and asked for the recipe before she'd even finished chewing—that's when I knew I'd stumbled onto something that bridges that gap between what tastes amazing and what actually fuels your body.

Ingredients

  • Lean ground beef: 300 g gives you that savory, umami-rich base that pepperoni alone can't deliver; don't skip browning it properly or you'll miss that nutty, caramelized flavor.
  • Turkey or regular pepperoni: 60 g sliced brings the pizza vibe; I prefer regular pepperoni because those crispy edges matter.
  • High-protein pasta: 350 g of penne or fusilli holds the sauce beautifully and keeps the texture interesting when baked.
  • Plain Greek yogurt: 250 g is the secret weapon—use full-fat if you can find it, and make sure it's truly plain or the tanginess will throw off your seasoning.
  • Part-skim mozzarella: 150 g shredded; buy it block-form and shred it yourself if time allows, it melts more evenly than pre-shredded.
  • Grated Parmesan: 40 g adds that sharp, salty edge that keeps everything from being one-note creamy.
  • Large egg: 1 binds everything and makes the sauce silky when it bakes.
  • Onion and garlic: The onion should be finely chopped so it softens completely, and the garlic minced small enough that you catch it in every bite.
  • Crushed tomatoes: 400 g canned is fine; avoid the ones with added sugar if you can.
  • Red bell pepper: Optional but worth including for sweetness and color—diced about the size of a small pea.
  • Baby spinach: 100 g roughly chopped sneaks greens in without anyone noticing they're there.
  • Oregano, basil, and chili flakes: Dried herbs work perfectly here; the chili flakes are optional but add a warmth that makes you reach for another forkful.
  • Olive oil: Just enough to coat the pan and prevent sticking—you're not deep frying.

Instructions

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Get your oven ready and prep the dish:
Set your oven to 200°C (400°F) and grease your baking dish lightly with olive oil or butter. A greased surface means no scraping regrets later.
Cook the pasta until just shy of tender:
Bring a large pot of salted water to a rolling boil, then add your pasta. The water should taste like the sea—this is the only seasoning the pasta gets. Drain when it still has a slight firmness to the bite, because it'll continue cooking in the oven.
Start building the meat sauce:
Heat a drizzle of olive oil in a large skillet over medium heat, then add your finely chopped onion and the diced bell pepper if using. You want them to turn translucent and sweet, about 3 to 4 minutes. The kitchen will smell incredible.
Introduce the garlic:
Stir in your minced garlic and let it bloom for about a minute—it should smell fragrant and lively, not burnt. If it starts browning too fast, your heat is too high.
Brown the ground beef thoroughly:
Add your lean ground beef to the pan and break it apart with a wooden spoon as it cooks. You want it to turn golden brown and slightly caramelized, not gray and steamed—this takes about 5 minutes. If there's excess fat pooling, tip some out.
Build the tomato base:
Pour in your crushed tomatoes, then sprinkle in the oregano, basil, and chili flakes if using. Add your chopped spinach if you're including it. Let this simmer gently for about 5 minutes so the flavors get to know each other. Taste and adjust salt and pepper—this is your moment to season boldly.
Create the yogurt-cheese mixture:
In a separate bowl, combine your Greek yogurt, half the shredded mozzarella, the grated Parmesan, and one large egg. Stir until completely smooth—no lumps of cheese should hide. Season lightly with salt and pepper, remembering that the Parmesan is already salty.
Bring it all together:
In a large bowl, combine your drained pasta, the beef-tomato mixture, and the yogurt-cheese sauce. Fold everything together gently but thoroughly so every strand of pasta gets coated. This is the point where you can taste and adjust seasoning one final time.
Transfer to the baking dish and top:
Pour the entire mixture into your prepared baking dish and spread it evenly. Scatter the remaining mozzarella over the top, then arrange your pepperoni slices in a pattern—or just scatter them carelessly, it honestly doesn't matter.
Bake until golden and bubbly:
Slide it into the preheated oven for 20 to 25 minutes. You're looking for the edges to bubble slightly, the cheese on top to turn golden, and a little browning around the rim. If the top isn't browning after 20 minutes, turn on the broiler for the last 2 minutes.
Rest before serving:
Let the bake sit for 5 minutes out of the oven—this lets everything set slightly so you don't get a runny spoonful. Use this time to pour a drink or set the table.
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A generous slice of High-Protein Pizza Pasta Bake served alongside a crisp green salad for dinner. Pin it
A generous slice of High-Protein Pizza Pasta Bake served alongside a crisp green salad for dinner. | freshymeals.com

The best moment was when my partner came home midway through baking and just stood in the doorway inhaling. That smell of melted cheese and browning meat and the faint tomato sweetness—it made him ask if we were having company. We weren't, and he seemed genuinely disappointed he'd have to share it.

Customizing Your Bake

The beauty of this dish is that it's flexible without falling apart. If you're out of Greek yogurt, a mix of ricotta and sour cream works, though you'll lose some of the protein benefit. Turkey or ground chicken will feel lighter and cook slightly faster, so watch it closely. Mushrooms sautéed with the onions add an earthy depth, and olives scattered through the mix bring a briny punch that feels very pizza-shop authentic.

Pairing and Serving Ideas

This bake is hearty enough to stand alone, but it sings when paired with something fresh and acidic. A simple green salad with lemon vinaigrette cuts through the richness, and a glass of Chianti or even a crisp white wine won't disappoint. Some people serve it with garlic bread, which is gilding the lily but absolutely nobody complains.

Storage and Make-Ahead Options

This is one of those recipes that actually improves after a day in the fridge—the flavors settle and deepen. You can assemble it completely the night before, cover it, and bake it straight from the cold, adding just 5 to 10 extra minutes to the baking time. Leftovers reheat beautifully either in the oven covered with foil or portioned into a microwave container, though the oven method keeps the texture more intact.

  • Freeze any extra for up to 3 months if your baking dish is freezer-safe, or transfer to a freezer container once cooled.
  • When reheating from frozen, thaw in the fridge overnight then bake at 180°C for about 20 minutes until warmed through.
  • This dish actually tastes better after a day or two, so there's no shame in making it on Sunday for the week ahead.
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Close-up of creamy High-Protein Pizza Pasta Bake with tender pasta, lean beef, and vibrant red bell peppers. Pin it
Close-up of creamy High-Protein Pizza Pasta Bake with tender pasta, lean beef, and vibrant red bell peppers. | freshymeals.com

This pasta bake has become my answer to the question of how to eat well without feeling deprived. It's the kind of dish that makes you feel taken care of, whether you're making it for yourself or for people you love.

Recipe FAQs

Can I make this ahead of time?

Yes, assemble the entire dish up to 24 hours in advance and refrigerate. Add 5-10 minutes to baking time if baking cold from the refrigerator.

What pasta shapes work best?

Penne and fusilli are ideal because their ridges and curves hold the sauce well. Rotini or macaroni also work nicely in this baked dish.

Can I freeze leftovers?

Absolutely. Portion into airtight containers and freeze for up to 3 months. Thaw overnight in the refrigerator and reheat in the oven or microwave.

How do I prevent the yogurt sauce from separating?

Whisk the egg thoroughly into the yogurt mixture before combining with hot pasta. The egg acts as a stabilizer. Also, avoid boiling once the yogurt is added.

Can I make it vegetarian?

Replace the ground beef with plant-based crumbles or extra vegetables like mushrooms and zucchini. Double the cheese or add white beans to maintain protein content.

What should I serve with this bake?

A crisp green salad with vinaigrette balances the richness. Roasted vegetables or steamed broccoli also complement the dish nicely. Crusty bread works for soaking up any extra sauce.

High-Protein Pizza Pasta Bake

A satisfying casserole blending pizza flavors with pasta, lean beef, and a tangy yogurt-cheese topping.

How long to prep
20 min
Time to cook
30 min
Overall time
50 min
Recipe by Freshymeals Lily Carter

Dish category Simple Comfort Plates

Skill level Easy

Cuisine type American-Italian

Makes 6 Serving size

Dietary details None specified

What you need

Proteins

01 300g lean ground beef
02 60g turkey or regular pepperoni, sliced

Pasta

01 350g high-protein pasta (penne or fusilli)

Cheese & Yogurt Sauce

01 1 cup plain Greek yogurt (0–2% fat)
02 1.5 cups part-skim mozzarella cheese, shredded
03 0.25 cup grated Parmesan cheese
04 1 large egg

Vegetables

01 1 small onion, finely chopped
02 2 cloves garlic, minced
03 14 oz canned crushed tomatoes
04 1 red bell pepper, diced (optional)
05 3.5 oz baby spinach, roughly chopped (optional)

Spices & Seasonings

01 1 teaspoon dried oregano
02 1 teaspoon dried basil
03 0.5 teaspoon chili flakes (optional)
04 Salt and black pepper, to taste
05 Olive oil, for sautéing

Steps to follow

Step 01

Prepare the oven and baking dish: Preheat the oven to 400°F. Grease a large 9x13-inch baking dish with olive oil or cooking spray.

Step 02

Cook the pasta: Cook the pasta in a large pot of salted boiling water until just al dente, following package directions. Drain and set aside.

Step 03

Sauté aromatics and vegetables: Heat a drizzle of olive oil in a large skillet over medium heat. Add the chopped onion and bell pepper if using; sauté for 3–4 minutes until softened.

Step 04

Cook garlic: Add the minced garlic and cook for 1 minute until fragrant.

Step 05

Brown the beef: Add the lean ground beef and cook, breaking it up with a spoon, until browned and cooked through. Drain excess fat if needed.

Step 06

Simmer the sauce: Stir in the crushed tomatoes, oregano, basil, chili flakes if using, and spinach if using. Simmer for 5 minutes. Season with salt and pepper to taste.

Step 07

Prepare the yogurt-cheese sauce: In a bowl, mix Greek yogurt, half of the mozzarella, Parmesan, and egg until smooth. Season lightly with salt and pepper.

Step 08

Combine all components: Combine the cooked pasta, beef-tomato mixture, and yogurt-cheese sauce in a large bowl. Mix until evenly coated.

Step 09

Assemble the bake: Transfer the mixture to the prepared baking dish. Top with remaining mozzarella and arrange pepperoni slices evenly over the surface.

Step 10

Bake until golden: Bake for 20–25 minutes until the top is bubbly and golden brown. Remove from oven and let rest for 5 minutes before serving.

Tools you’ll need

  • Large pot for pasta cooking
  • Large skillet for browning meat and sautéing vegetables
  • Mixing bowls for combining ingredients
  • 9x13-inch baking dish
  • Knife and cutting board for ingredient preparation
  • Spoon or spatula for stirring and mixing

Allergy info

Always check each ingredient for allergens and talk to a professional if unsure.
  • Contains milk (cheese and yogurt)
  • Contains eggs
  • Contains wheat (pasta, unless gluten-free alternative used)
  • Pre-sliced pepperoni may contain soy or additional gluten; verify ingredient label

Nutrition info (per portion)

Nutrition details are for reference only, not a substitute for health advice.
  • Calories per serving: 420
  • Fat content: 13 g
  • Carbohydrates: 39 g
  • Protein amount: 37 g