Baked High-Protein Pepperoni Stromboli

Featured in: Simple Comfort Plates

This satisfying stromboli delivers 26 grams of protein per serving, combining seasoned lean ground beef, zesty pepperoni, and a blend of mozzarella and Parmesan cheeses. The filling is rolled into refrigerated pizza dough, brushed with egg wash for a glossy golden crust, and baked until perfectly crisp. The result is a hearty handheld meal that's ideal for dinner or meal prep, with generous vents allowing steam to escape for even cooking throughout.

Updated on Mon, 09 Feb 2026 16:30:00 GMT
Golden-brown Baked High-Protein Pepperoni Stromboli sliced open on a wooden cutting board, revealing layers of melted mozzarella, pepperoni, and seasoned ground beef. Pin it
Golden-brown Baked High-Protein Pepperoni Stromboli sliced open on a wooden cutting board, revealing layers of melted mozzarella, pepperoni, and seasoned ground beef. | freshymeals.com

There's something about the smell of pepperoni crisping up in the oven that makes you feel like you're doing something right in the kitchen. I stumbled onto this stromboli recipe on a Tuesday when I was tired of the same old weeknight routine and wanted something that felt like actual cooking, not just assembly. The first time I rolled it up, I was convinced the filling would burst everywhere, but instead, it stayed tucked inside that golden dough like a secret. Now it's become my go-to when I need to feed people something impressive without spending hours in front of the stove.

My sister came over one afternoon when this was cooling on the counter, and she grabbed a warm slice before I could even plate it properly. Her eyes went wide, and she said it tasted like the stromboli from that Italian deli downtown but somehow better. That moment made me realize it wasn't just about the ingredients, it was about nailing the technique and not being afraid to let the flavors shine.

Ingredients

  • Refrigerated pizza dough (1 pound): This is your time-saver, and honestly, there's no shame in using it. Quality store-bought dough often outperforms homemade when you're short on time.
  • Lean ground beef (1/2 pound): The protein powerhouse here. Browning it properly means rendering out the fat for a cleaner, less greasy filling.
  • Salt and black pepper (1/2 teaspoon each): These aren't just seasoning, they're flavor amplifiers that make the beef taste like itself, only better.
  • Dried oregano and garlic powder (1/2 teaspoon each): These dried herbs actually work better here than fresh because they stay concentrated during baking.
  • Mozzarella and Parmesan cheese (1 cup and 1/2 cup): The combo is key, mozzarella melts into rivers of gooey goodness while Parmesan adds a sharp, nutty depth.
  • Sliced pepperoni (3 ounces): Buy the good stuff if you can, the better quality pepperoni will actually cup up and crisp at the edges.
  • Pizza sauce (1/4 cup): A thin layer is all you need, too much and the dough gets soggy instead of crispy.
  • Beaten egg and olive oil: This is your golden-brown guarantee, the egg wash creates shine and the oil adds final crispness.

Instructions

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Heat your oven and prepare:
Set the oven to 400°F and line your baking sheet with parchment paper. This is non-negotiable if you want a crispy bottom without sticking.
Brown the beef properly:
Cook the ground beef in a skillet over medium heat with your salt, pepper, oregano, and garlic powder, breaking it up as it cooks. Once it's fully browned and the excess fat is drained, let it cool for a minute or two so it doesn't warm up the cheese when you layer it.
Roll out the dough:
On a floured surface, stretch your pizza dough into a rectangle about 12 by 16 inches. If it springs back, let it rest for a minute and try again, it's actually telling you it needs a breather.
Spread the sauce thinly:
Cover the dough with pizza sauce, but leave a 1-inch border on all sides. This border is your seal, it keeps everything locked in.
Layer your fillings evenly:
Scatter your cooled beef first, then the mozzarella, Parmesan, and pepperoni in that order. Think of it like you're making sure every bite gets a piece of everything.
Roll it tight:
Starting from one long edge, roll the dough tightly into a log, then pinch the seam and twist the ends closed like you're sealing a burrito. A tight roll is what keeps everything from leaking out.
Transfer and seal:
Place the stromboli seam-side down on your prepared baking sheet. This position keeps the seam from opening as it bakes.
Add the egg wash and oil:
Brush the top with beaten egg and drizzle lightly with olive oil. You'll see it transform into something restaurant-quality as it bakes.
Vent and bake:
Make a few diagonal slits across the top with a sharp knife to let steam escape. Bake for 25 to 30 minutes until it's golden brown and feels set when you gently press it.
Rest before slicing:
Let it cool for 5 to 10 minutes, this is when the magic happens and everything sets up so you don't get cheese and meat spilling out.
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Sliced wedges of Baked High-Protein Pepperoni Stromboli served on a white plate with a small dish of warm pizza sauce for dipping. Pin it
Sliced wedges of Baked High-Protein Pepperoni Stromboli served on a white plate with a small dish of warm pizza sauce for dipping. | freshymeals.com

There was a Saturday morning when I made this for a breakfast gathering, and it sounds weird, but people kept coming back to slice off another piece. By the end, it was gone in twenty minutes, and someone asked if I could teach them how to make it. That's when it clicked that this wasn't just a recipe, it was something that brought people together.

Variations to Keep It Fresh

Once you nail the basic version, it's fun to experiment with what goes inside. I've swapped the beef for ground turkey to lighten things up, and honestly, it's just as satisfying because the pepperoni and cheese do most of the heavy lifting. You could also add sautéed bell peppers or onions to the filling if you want more texture and flavor, just make sure they're cooked down first so they don't release water into the filling.

The Resting Window Really Matters

I used to cut into the stromboli right out of the oven because I was impatient, and the filling would slide everywhere. Now I know those 5 to 10 minutes are when everything sets and the cheese firms up just enough to hold its shape. It's a small detail, but it completely changes whether you get neat slices or a delicious mess.

Serving and Storage

Serve this warm with extra pizza sauce on the side for dipping, it's the perfect vehicle for one more flavor hit. Leftovers keep beautifully in the fridge and actually taste great cold the next day, or you can reheat slices in a 350°F oven for about 8 minutes to bring back the crispness.

  • Pair it with a simple green salad to balance out the richness.
  • Make extra and freeze the unbaked stromboli, then bake straight from frozen, adding 10 extra minutes to the bake time.
  • Leftovers work great for lunch boxes because they stay intact and taste just as good cold.
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Freshly baked Baked High-Protein Pepperoni Stromboli resting on a parchment-lined baking sheet, steam rising from the golden crust. Pin it
Freshly baked Baked High-Protein Pepperoni Stromboli resting on a parchment-lined baking sheet, steam rising from the golden crust. | freshymeals.com

This stromboli has become my secret weapon for when I want to cook something that tastes impressive but doesn't feel like a chore. It's the kind of dish that reminds you why you love spending time in the kitchen.

Recipe FAQs

What makes this stromboli high-protein?

The combination of lean ground beef, pepperoni, and generous amounts of mozzarella and Parmesan cheese provides 26 grams of protein per serving, making it substantially more protein-rich than traditional versions.

Can I prepare this ahead of time?

Yes, you can assemble the stromboli, wrap it tightly in plastic, and refrigerate for up to 24 hours before baking. Let it sit at room temperature for 15 minutes before brushing with egg and placing in the oven.

How do I prevent the filling from leaking during baking?

Ensure you pinch the seam and ends tightly to seal, and let the cooked beef cool slightly before assembling. The vent slits on top also help release steam pressure that could force filling out.

Can I freeze baked stromboli?

Absolutely. Bake completely, cool, wrap tightly in foil and freeze for up to 3 months. Thaw overnight in the refrigerator and reheat in a 350°F oven for 10-15 minutes until heated through.

What should I serve with stromboli?

Warm pizza sauce for dipping is essential. A crisp green salad with vinaigrette, roasted vegetables, or soup make excellent sides. The stromboli is substantial enough to stand alone as a complete meal.

Baked High-Protein Pepperoni Stromboli

Protein-packed stromboli with beef, pepperoni and cheese baked to golden perfection in pizza dough.

How long to prep
25 min
Time to cook
30 min
Overall time
55 min
Recipe by Freshymeals Lily Carter

Dish category Simple Comfort Plates

Skill level Medium

Cuisine type Italian-American

Makes 6 Serving size

Dietary details None specified

What you need

Dough

01 1 pound refrigerated pizza dough

Filling

01 1/2 pound lean ground beef
02 1/2 teaspoon salt
03 1/2 teaspoon black pepper
04 1/2 teaspoon dried oregano
05 1/2 teaspoon garlic powder
06 1 cup shredded mozzarella cheese
07 1/2 cup grated Parmesan cheese
08 3 ounces sliced pepperoni
09 1/4 cup pizza sauce plus extra for serving
10 1 tablespoon chopped fresh parsley optional

For Brushing

01 1 egg beaten
02 1 tablespoon olive oil

Steps to follow

Step 01

Prepare Oven and Pan: Preheat oven to 400°F. Line a baking sheet with parchment paper.

Step 02

Brown Ground Beef: In a skillet over medium heat, cook the ground beef with salt, pepper, oregano, and garlic powder until fully browned. Drain excess fat and allow to cool slightly.

Step 03

Roll Out Dough: On a floured surface, roll out the pizza dough into a large rectangle approximately 12 by 16 inches.

Step 04

Apply Sauce Base: Spread the pizza sauce evenly over the dough, leaving a 1-inch border along all edges.

Step 05

Layer Filling Components: Evenly distribute the cooked beef, mozzarella cheese, Parmesan cheese, and pepperoni slices over the sauce.

Step 06

Roll and Seal: Starting from one long edge, tightly roll up the dough into a log, pinching the seam and ends firmly to seal.

Step 07

Position on Baking Sheet: Transfer the stromboli to the prepared baking sheet with the seam side facing down.

Step 08

Apply Egg Wash: Brush the top of the stromboli with beaten egg and drizzle with olive oil for golden browning and crispness.

Step 09

Vent the Dough: Using a sharp knife, make several diagonal slits across the top to allow steam to escape during baking.

Step 10

Bake Until Golden: Bake for 25 to 30 minutes until the crust is golden brown and the filling is cooked through.

Step 11

Rest and Serve: Cool for 5 to 10 minutes before slicing to keep the filling intact. Garnish with fresh parsley if desired and serve warm with extra pizza sauce for dipping.

Tools you’ll need

  • Skillet
  • Baking sheet
  • Parchment paper
  • Rolling pin
  • Sharp knife
  • Pastry brush

Allergy info

Always check each ingredient for allergens and talk to a professional if unsure.
  • Contains wheat and gluten
  • Contains milk and dairy
  • Contains eggs
  • Pepperoni may contain soy and other potential allergens—verify labels if sensitive

Nutrition info (per portion)

Nutrition details are for reference only, not a substitute for health advice.
  • Calories per serving: 410
  • Fat content: 22 g
  • Carbohydrates: 29 g
  • Protein amount: 26 g