High-Protein Pizza Pasta Bake

Featured in: Simple Comfort Plates

This satisfying pasta bake delivers 31g of protein per serving by combining high-protein pasta with lean ground beef and pepperoni. The creamy sauce blends Greek yogurt with mozzarella and Parmesan for rich flavor without excess calories. Simply brown the beef with vegetables, toss with pasta and sauce, then bake until bubbly and golden. Perfect for meal prep or family dinners, this American-Italian fusion holds well and reheats beautifully.

Updated on Mon, 09 Feb 2026 20:50:18 GMT
Golden, bubbly mozzarella and crispy pepperoni top a hearty High-Protein Pizza Pasta Bake fresh from the oven. Pin it
Golden, bubbly mozzarella and crispy pepperoni top a hearty High-Protein Pizza Pasta Bake fresh from the oven. | freshymeals.com

Experience the ultimate comfort food with a healthy twist in this High-Protein Pizza Pasta Bake. This dish perfectly marries the savory, bold flavors of a classic pepperoni pizza with the hearty, satisfying nature of a warm pasta casserole. It is an ideal choice for busy weeknights or as a high-protein meal prep option that doesn't compromise on taste.

Golden, bubbly mozzarella and crispy pepperoni top a hearty High-Protein Pizza Pasta Bake fresh from the oven. Pin it
Golden, bubbly mozzarella and crispy pepperoni top a hearty High-Protein Pizza Pasta Bake fresh from the oven. | freshymeals.com

What sets this recipe apart is the creamy, protein-packed sauce made with Greek yogurt and melty mozzarella. It provides a luxurious texture that normally requires heavy cream, but here it keeps the nutritional profile lean. Combined with lean ground beef and zesty pepperoni, every bite is a delightful explosion of flavor.

Ingredients

  • Pasta
  • 12 oz (340 g) high-protein penne or rotini pasta
  • Meats
  • 8 oz (225 g) lean ground beef
  • 2 oz (55 g) turkey or regular pepperoni, sliced
  • Vegetables & Aromatics
  • 1 medium onion, finely chopped
  • 2 cloves garlic, minced
  • 1 bell pepper, diced (optional)
  • 1 cup (150 g) sliced mushrooms (optional)
  • Sauce
  • 2 cups (480 ml) low-sodium marinara sauce
  • 1 cup (240 g) plain Greek yogurt (2% or fat-free)
  • 1 cup (110 g) part-skim shredded mozzarella cheese
  • ¼ cup (25 g) grated Parmesan cheese
  • ½ tsp dried oregano
  • ½ tsp dried basil
  • ¼ tsp crushed red pepper flakes (optional)
  • Salt and black pepper, to taste
  • Topping
  • ½ cup (55 g) part-skim shredded mozzarella cheese
  • 1 oz (28 g) pepperoni, extra, for topping
  • Fresh basil or parsley, chopped (optional)
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Instructions

Step 1
Preheat oven to 375°F (190°C). Grease a 9x13-inch (23x33 cm) baking dish.
Step 2
Cook pasta in a large pot of salted boiling water until just al dente. Drain and set aside.
Step 3
Meanwhile, in a large skillet over medium heat, cook ground beef, breaking it up, until browned and cooked through. Add onion and cook 3–4 minutes until softened. Stir in garlic, bell pepper, and mushrooms; sauté another 3 minutes. Drain excess fat if needed.
Step 4
Stir in marinara sauce, oregano, basil, and red pepper flakes. Simmer for 5 minutes. Season with salt and pepper.
Step 5
In a bowl, whisk together Greek yogurt, 1 cup mozzarella, and Parmesan until smooth.
Step 6
In a large mixing bowl, combine cooked pasta, beef-vegetable sauce, sliced pepperoni, and yogurt-cheese mixture. Toss well to coat.
Step 7
Transfer mixture to prepared baking dish. Top with remaining ½ cup mozzarella and extra pepperoni slices.
Step 8
Bake uncovered for 20 minutes, until bubbly and golden.
Step 9
Let rest 5 minutes before garnishing with fresh basil or parsley. Serve warm.

Zusatztipps für die Zubereitung

To ensure the dish remains lean, focus on the quality of your protein. You can substitute the ground beef with ground turkey or chicken if desired. Be sure to drain any excess fat after browning the meat and sautéing the vegetables to keep the sauce clean and flavorful.

Varianten und Anpassungen

For an extra nutrient boost, feel free to add spinach, zucchini, or olives to the vegetable mix. To increase fiber and protein even further, use whole-wheat or chickpea-based pasta. If you have dietary restrictions, check labels for gluten-free pasta and nitrate-free pepperoni options.

Serviervorschläge

Serve this hearty pasta bake with a fresh green salad to add a light, crunchy element to your meal. For those who enjoy a complete experience, a glass of dry Italian red wine pairs beautifully with the savory, herb-infused marinara sauce.

A close-up of creamy, cheesy High-Protein Pizza Pasta Bake served in a rustic dish with fresh basil garnish. Pin it
A close-up of creamy, cheesy High-Protein Pizza Pasta Bake served in a rustic dish with fresh basil garnish. | freshymeals.com

Whether you are feeding a hungry family or looking for a delicious way to hit your protein goals, this High-Protein Pizza Pasta Bake is a winner. Its blend of classic Italian-American flavors and wholesome ingredients makes it a recipe you will return to time and time again. Enjoy your meal!

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Recipe FAQs

Can I use regular pasta instead of high-protein pasta?

Yes, regular penne or rotini works perfectly. Whole-wheat or chickpea pasta adds extra fiber and protein if you want to boost the nutritional content.

How long does this pasta bake last in the refrigerator?

Store covered in the refrigerator for up to 4 days. Reheat individual portions in the microwave or cover with foil and warm in a 350°F oven.

Can I freeze this pasta bake?

Absolutely. Assemble the dish, wrap tightly with foil and plastic wrap, and freeze for up to 3 months. Thaw overnight in the refrigerator before baking.

What makes this dish high in protein?

The combination of high-protein pasta, lean ground beef, Greek yogurt, and mozzarella cheese delivers 31g of protein per serving, making it ideal for muscle recovery.

Can I make this vegetarian?

Replace the beef with plant-based crumbles or extra vegetables like mushrooms, spinach, and zucchini. The yogurt-cheese sauce still provides plenty of protein.

High-Protein Pizza Pasta Bake

Protein-packed comfort with beef, pepperoni, and creamy sauce baked to golden perfection.

How long to prep
20 min
Time to cook
30 min
Overall time
50 min
Recipe by Freshymeals Lily Carter

Dish category Simple Comfort Plates

Skill level Easy

Cuisine type American-Italian

Makes 6 Serving size

Dietary details None specified

What you need

Pasta

01 12 oz high-protein penne or rotini pasta

Meats

01 8 oz lean ground beef
02 2 oz turkey or regular pepperoni, sliced

Vegetables and Aromatics

01 1 medium onion, finely chopped
02 2 cloves garlic, minced
03 1 bell pepper, diced
04 1 cup sliced mushrooms

Sauce

01 2 cups low-sodium marinara sauce
02 1 cup plain Greek yogurt, 2% or fat-free
03 1 cup part-skim shredded mozzarella cheese
04 1/4 cup grated Parmesan cheese
05 1/2 teaspoon dried oregano
06 1/2 teaspoon dried basil
07 1/4 teaspoon crushed red pepper flakes
08 Salt and black pepper to taste

Topping

01 1/2 cup part-skim shredded mozzarella cheese
02 1 oz pepperoni, sliced
03 Fresh basil or parsley, chopped

Steps to follow

Step 01

Prepare Baking Dish and Preheat Oven: Preheat oven to 375°F. Grease a 9x13-inch baking dish with cooking spray or butter.

Step 02

Cook Pasta to Al Dente: Bring a large pot of salted water to boil. Add pasta and cook according to package directions until just al dente. Drain well and set aside.

Step 03

Brown Ground Beef: Heat a large skillet over medium heat. Add ground beef, breaking it apart with a spoon, until fully browned and cooked through, approximately 5 to 7 minutes. Transfer to a plate if needed.

Step 04

Sauté Aromatics and Vegetables: In the same skillet, add chopped onion and cook for 3 to 4 minutes until softened. Stir in minced garlic, diced bell pepper, and sliced mushrooms. Sauté for an additional 3 minutes until vegetables are tender. Return ground beef to the skillet if removed.

Step 05

Build the Meat Sauce: Stir in marinara sauce, dried oregano, dried basil, and crushed red pepper flakes. Simmer the mixture for 5 minutes. Season with salt and black pepper to taste. Drain excess fat if necessary.

Step 06

Prepare Yogurt-Cheese Mixture: In a medium bowl, whisk together Greek yogurt, 1 cup mozzarella cheese, and grated Parmesan cheese until smooth and well combined.

Step 07

Combine All Components: In a large mixing bowl, combine the cooked pasta, beef-vegetable sauce, sliced pepperoni, and yogurt-cheese mixture. Toss thoroughly until all ingredients are evenly coated.

Step 08

Transfer to Baking Dish: Pour the pasta mixture into the prepared 9x13-inch baking dish, spreading it evenly.

Step 09

Add Final Toppings: Sprinkle the remaining 1/2 cup mozzarella cheese over the top and distribute additional pepperoni slices across the surface.

Step 10

Bake Until Golden and Bubbly: Bake uncovered for 20 minutes until the cheese is melted, the edges are bubbly, and the top is golden brown.

Step 11

Rest and Finish: Remove from oven and allow the dish to rest for 5 minutes. Garnish with fresh chopped basil or parsley. Serve while warm.

Tools you’ll need

  • Large pot with lid for cooking pasta
  • Large skillet for browning meat and sautéing vegetables
  • Medium and large mixing bowls
  • 9x13-inch rectangular baking dish
  • Whisk for combining yogurt-cheese mixture
  • Spatula or wooden spoon for tossing ingredients

Allergy info

Always check each ingredient for allergens and talk to a professional if unsure.
  • Contains wheat from pasta
  • Contains milk from mozzarella cheese, Parmesan cheese, and Greek yogurt
  • Pepperoni may contain sulfites and nitrates
  • Use certified gluten-free pasta and nitrate-free pepperoni for allergen-free preparation if required

Nutrition info (per portion)

Nutrition details are for reference only, not a substitute for health advice.
  • Calories per serving: 410
  • Fat content: 13 g
  • Carbohydrates: 40 g
  • Protein amount: 31 g